Technologies
Our state-of-the-art portfolio of biophysical technologies enables us to provide you with a complete and comprehensive picture of your specific question: From affinity and stability to kinetics and thermodynamics.
KD | EC50 | Tm | ΔTm | Tagg | ΔTagg | kon | koff | n | ΔH | ΔG | ΔS | rh | PDI | Tsize | kD
Automated MST
APPLICATION AREAS
- Drug discovery
- Fragment screening
- Compound screening
- Protein interaction analysis
PARAMETERS
- Single-dose binding
- Steady-state affinity (KD)
NANOTEMPER CERTIFIED SERVICE PROVIDER
Dianthus
APPLICATION AREAS
- Drug discovery
- Fragment screening
- Compound screening
PARAMETERS
- Single-dose binding
- Steady-state affinity (KD)
NANOTEMPER CERTIFIED SERVICE PROVIDER
WAVEsystem
APPLICATION AREAS
- Drug discovery
- Fragment screening
- Compound screening
- Off-rate ranking
- Biologics development
PARAMETERS
- Binding kinetics (kon, ka, koff, kd)
- Steady-state affinity (KD)
- Enthalpy (ΔH)
CREOPTIX CERTIFIED SERVICE PROVIDER
MST
APPLICATION AREAS
- Small-scale interaction analysis
- Assay development
- Aptamer binding
- Protein-protein interaction analysis
- Competition assays
PARAMETERS
- Single-dose binding
- Steady-state affinity (KD)
NANOTEMPER CERTIFIED SERVICE PROVIDER
nanoDSF
APPLICATION AREAS
- Protein stability and unfolding analysis
- Buffer screening and optimization
- Protein aggregation analysis
- Pre- and formulation development
- Ligand binding (thermal shift)
PARAMETERS
- Protein unfolding (Tm, Tonset, Tturbidity, kd)
- Binding (Tm-diff, EC50)
NANOTEMPER CERTIFIED SERVICE PROVIDER
DLS
APPLICATION AREAS
- Protein quality control
- Particle size determination
- Solutio homogeneity
- Protein aggregation analysis
- Pre- and formulation development
- Buffer screening and optimization
PARAMETERS
- Paticle parameters (rh, PDI)
- Aggregation analysis (Tsize, Tscattering)
NANOTEMPER CERTIFIED SERVICE PROVIDER
BLI
APPLICATION AREAS
- Biologics development
- Antibody-antigen interaction analysis
- Off-rate ranking
PARAMETERS
- Binding kinetics (kon, ka, koff, kd)
- Steady-state affinity (KD)
- Enthalpy (ΔH)
ITC
APPLICATION AREAS
- Thermodynamic interaction analysis
- Drug discovery
- Compound and fragment binding
- Protein-protein interaction analysis
PARAMETERS
- Steady-state affinity (KD)
- Binding stoichiometry (n)
- Binding thermodynamics (ΔH, ΔS, ΔG)
LabCyte Echo
APPLICATION AREAS
- Compound spotting/printing
- Fragment spotting/printing
- Contact-free, high-precision dilution series
- Industry-standard