Isothermal Titration Calorimetry – Typical applications

Isothermal Titration Calorimetry – Typical applications

Determining enthalpic and entropic contribution to molecular interactions


Determining changes in free energy upon molecular binding


Determining stoichiometry of molecular interactions


in various contexts:
protein-protein interactions
protein-DNA interactions
protein-RNA interactions
protein-small molecule interactions
DNA-small molecule interactions
RNA-small molecule interactions


For notes describing the use of ITC systems for the characterization of biomolecular interactions please refer to application notes provided by Malvern Instruments