“Epigenetics” is most commonly used to describe chromatin-based processes that regulate all kind of DNA dependent processes. Epigenetic regulation is exerted by DNA and histone modifications and the specific recognition of these modifications by RNA and protein complexes. Modifications to DNA and histones are dynamically set and removed by chromatin-modifying enzymes in a highly regulated manner. Currently, there are four different DNA modifications. The DNA and histone code is set by so called writer molecules (methylases, kinases, acetylases and others) that modify histones and DNA. These chromatin marks are specifically recognized by so called reader molecules that were shown to alter chromatin structure by non-covalent interactions with and between nucleosomes. The type and combination of sequestered protein/RNA readers determine the function of the underlying chromatin domain. In a regulated fashion the activity of such chromatin domains is changed by the recruitment of eraser molecules that remove and change local DNA and histone marks (deacetylases, demethylases and others). Epigenetic regulation is determined by a complex regulatory network that relies on the specific recognition of the chromatin template.
To understand complex epigenetic regulation systems it is of special interest for scientist to have useful chromatin templates and sophisticated biophysical analytical capabilities.
2bind offers both!
2bind – your reliable partner for epigenetic studies
As a spin-off from the epigenetics lab of Prof. Dr. Gernot Längst, University of Regensburg, Germany, 2bind has a broad knowledge in epigenetics and in epigenetic tools. Various connections to leading scientists in the epigenetic field allow us to constantly improve our expertise.
1. The production of various chromatin templates